Not much is known about Seaxburh of Wessex. She was married to Cenwalh, King of Wessex, who had discarded his first wife to marry her. He died around 672 and had no children by her, or any other woman. She is said to have ruled Wessex on her own after the death of her husband. She is the only woman to have ruled Wessex.
She probably died around 674 as the next reign entered into the Anglo-Saxon Chronicle begins that year. She was succeeded by Æscwine. It is unfortunate that we do not know more.